Summary of Human Studies
on NMN

This study examined whether NMN affects how insulin, the hormone that lowers blood glucose, works in the body.

In a study of women with prediabetes, continued NMN intake increased the ability of skeletal muscle to use glucose from the blood for energy.

The study also found activation of biological pathways involved in glucose metabolism, suggesting that NMN may help support healthy glucose metabolism.

This study examined the effects of NMN on physical function in older adults with diabetes and impaired physical performance.

Assessments of physical function, including muscle strength and walking ability, showed no substantial overall changes, although some measures showed a trend toward improvement. Blood tests also confirmed increases in NAD+-related metabolites, indicating that NMN was absorbed and utilized in the body. These findings suggest that NMN may be safe for older adults to consume and may help support health maintenance and physical function.

This study examined whether NMN intake affects endurance during exercise.

In a study of amateur runners, six weeks of NMN supplementation improved the body’s ability to use oxygen efficiently during exercise and improved measures related to endurance. These findings suggest that NMN may help support the maintenance and improvement of exercise performance and endurance.

This study examined how NMN intake affects NAD levels, walking speed, and sleep quality.

In a study of older adults, continued NMN intake increased NAD levels in the body. The study also reported maintenance of walking speed, which tends to decline with age, and improvements in sleep quality. These findings suggest that NMN may help maintain healthy physical function and support activity in daily life.

This study examined the effects of NMN on muscle responses after training performed with mild blood-flow restriction.

In a study of healthy adults, the group receiving NMN showed reductions in markers associated with muscle inflammation after exercise. Favorable changes were also observed in biological responses related to muscle recovery, suggesting that NMN may reduce the physical burden associated with exercise. These findings suggest that NMN may help support post-exercise conditioning and muscle recovery.

Participants took NMN for 12 weeks, and the study assessed its effects on sleep, fatigue, and physical performance.

In a study of older Japanese adults, 12 weeks of continued NMN intake was associated with improvements in sleep quality and daytime drowsiness. The study also reported findings suggesting reduced fatigue and maintenance of physical function, indicating that NMN may help support activity in daily life. These findings suggest that NMN may help maintain health and improve quality of life in older adults.

This study examined the relationship between NMN intake and sleep quality.

In a study of older adults, the group receiving NMN showed increased NAD levels in the body, maintenance of walking speed, and improved sleep quality. Favorable changes were observed particularly in measures related to daily activity and the quality of rest, suggesting that NMN may help support a healthy lifestyle.

This study examined the effects of NMN intake on energy metabolism and vascular health.

In a study of middle-aged and older adults, long-term NMN intake increased NAD-related metabolites in the body. Favorable changes were also observed in markers related to arterial flexibility, suggesting that NMN may help maintain vascular health, which tends to decline with age. These findings suggest that NMN may help maintain healthy vascular function.

This study examined changes in clinical laboratory results and metabolites after NMN intake.

In a study of healthy Japanese men, no serious adverse events were observed following NMN intake, and no major safety concerns were identified. NAD-related metabolites also increased after NMN intake, indicating that the ingested NMN was utilized in the body. These findings suggest that NMN may be safe to consume and may help support the availability of NAD, which is involved in maintaining normal bodily functions.

This study evaluated the effects and safety of different NMN intake levels.

In a study of healthy middle-aged and older adults, continued NMN intake was associated with improvements in measures of muscle strength and physical function. No serious adverse events were observed during the study, and the safety findings were favorable. These results suggest that NMN may help maintain physical function with age and support healthy daily living.

This study examined how NMN intake affects NAD, an important substance involved in the body’s energy production.

In a study of middle-aged and older adults, NMN intake substantially increased NAD-related metabolites in the body. No serious adverse events were observed during the study, and favorable safety findings were reported. These findings suggest that NMN may help support NAD levels, which are thought to decline with age, and may contribute to health maintenance.

This study assessed whether NMN intake caused any health concerns.

In a study of healthy adult men and women, NMN intake was not associated with serious adverse events or major health concerns. Blood tests and physical examinations also identified no safety-related abnormalities, and the study reported favorable safety findings. These results suggest that NMN may be safe for healthy adults to consume.

This study examined how energy-related compounds, including NMN, affect metabolites in the body and the activity of gut microorganisms.

In a study of healthy adults, intake of NAD precursors, including NMN, increased NAD-related metabolites in the body. The study also found that the compounds differed in how they were processed and utilized, and showed that NMN can be effectively used as one of the precursors for NAD production. These findings suggest that NMN may help maintain NAD levels in the body and support health maintenance.